Practical approach to N-benzyl derivatives of 2-amino-8-methoxy-4H-chromene-3-carbonitrile by reductive amination: Exploration of their effects against protein kinases and in silico ADME profiling

The synthesis of 2-benzylamino-8-methoxy-4H-chromene-3-carbonitriles 7(a-e) has been realized in four steps, via reductive amination from the 2-amino-8-methoxy-4H-chromene-3-carbonitrile 4 as key intermediate platform with para- and meta-substituted benzaldehydes 5(a-e), good overall yields. physicochemical properties also their aldimines 6(a-e) precursors have determined using Swiss ADME server according to Lipinski's descriptors. Biological assays a panel six protein kinases such HsCDK5-p25, HsCDK9/cyclin T, HsPim1, HsHaspin, SscGSK-3a/β SscCK1δ/ε showed that 6(a,b) 6e are potentially interesting because they percentage residual activities against HsPim1 HsHaspin.